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1 "Daysi Yazmin Rodríguez Ochoa"
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Original Article
Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus
Anel Gómez García, Mireya Rivera Rodríguez, Carlos Gómez Alonso, Daysi Yazmin Rodríguez Ochoa, Cleto Alvarez Aguilar
Diabetes Metab J. 2015;39(1):59-65.   Published online February 16, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.1.59
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  • 36 Web of Science
  • 32 Crossref
AbstractAbstract PDFPubReader   
Background

Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM.

Methods

Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase.

Results

MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879).

Conclusion

MPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.

Citations

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    International Journal of Molecular Sciences.2023; 24(15): 12078.     CrossRef
  • Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery
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  • Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase
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    Nutrients.2023; 15(22): 4776.     CrossRef
  • Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin
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    World Journal of Diabetes.2022; 13(3): 224.     CrossRef
  • Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
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    International Journal of Molecular Sciences.2022; 23(18): 10735.     CrossRef
  • Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer
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    International Journal of Molecular Sciences.2022; 23(20): 12250.     CrossRef
  • Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women
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    Amino Acids.2021; 53(3): 333.     CrossRef
  • Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus
    Lu Peng, Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin, Huina Zhang
    Clinica Chimica Acta.2021; 522: 70.     CrossRef
  • Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males
    Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Straßburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. Sreekumaran Nair, Andreas S. Reichert, Stefan Lehr
    Science Advances.2021;[Epub]     CrossRef
  • Increased Oxidative Stress in Gastric Cancer Patients and Their First-Degree Relatives: A Prospective Study from Northeastern Brazil
    Manuel B. Braga-Neto, Deiziane V. S. Costa, Dulciene M. M. Queiroz, Felipe S. Maciel, Michelle S. de Oliveira, Antônio B. Viana-Junior, Flávia A. Santos, Renata F. C. Leitao, Gerly A. C. Brito, Paulo R. L. Vasconcelos, Lucia L. B. C. Braga, Ilaria Peluso
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1
    Tiziana Bacchetti, Gianna Ferretti, Federico Carbone, Stefano Ministrini, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar
    Current Medicinal Chemistry.2021; 28(14): 2842.     CrossRef
  • Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
    Mohammad G. Qaddoumi, Muath Alanbaei, Maha M. Hammad, Irina Al Khairi, Preethi Cherian, Arshad Channanath, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker
    Scientific Reports.2020;[Epub]     CrossRef
  • The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
    Gholamreza Daryabor, Mohamad Reza Atashzar, Dieter Kabelitz, Seppo Meri, Kurosh Kalantar
    Frontiers in Immunology.2020;[Epub]     CrossRef
  • The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease
    Michael J. Davies, Clare L. Hawkins
    Antioxidants & Redox Signaling.2020; 32(13): 957.     CrossRef
  • Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients
    Michael Alexandrovski, Soimita Suciu, Jakob Alexandrovski
    BioResearch Open Access.2020; 9(1): 190.     CrossRef
  • Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus
    Mokerroma Ferdous, Sonam C. R, Sonchita R. Mudi, Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M.K. Alam, M.I. Arslan, Subrata K. Biswas
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(2): 83.     CrossRef
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    Arnold Piek, Debby P. Y. Koonen, Elisabeth-Maria Schouten, Eva L. Lindtstedt, Erik Michaëlsson, Rudolf A. de Boer, Herman H. W. Silljé
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  • Significance of Myeloperoxidase in the Onset of Cardiovascular Disease among Obese Children and Adolescents
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  • Postprandial activation of leukocyte‐endothelium interaction by fatty acids in the visceral adipose tissue microcirculation
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  • Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
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    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(12): 1345.     CrossRef
  • Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects
    Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M. K. Alam, M. I. Arslan, Subrata K. Biswas
    Molecular Biology Reports.2018; 45(5): 1245.     CrossRef
  • Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
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    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Association of Interleukin-6 and Myeloperoxidase with Insulin Resistance in Impaired Fasting Glucose Subjects
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    Indian Journal of Clinical Biochemistry.2017; 32(1): 33.     CrossRef
  • Association Between Tumor Necrosis Factor-α and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: a Meta-Analysis
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    Molecular Neurobiology.2017; 54(2): 983.     CrossRef
  • Bipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report
    Rodrigo B. Mansur, Lucas B. Rizzo, Camila M. Santos, Elson Asevedo, Graccielle R. Cunha, Mariane N. Noto, Mariana Pedrini, Maiara Zeni-Graiff, Eduardo S. Gouvea, Quirino Cordeiro, Eva Z. Reininghaus, Roger S. McIntyre, Elisa Brietzke
    Journal of Psychiatric Research.2016; 80: 38.     CrossRef
  • Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder
    Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Graccielle R Cunha, Elson Asevedo, Mariane N Noto, Mariana Pedrini, Maiara Zeni, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
    Bipolar Disorders.2016; 18(5): 433.     CrossRef
  • A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease
    Pei-Wen Zhang, Feng-Xia Chen, Di Li, Wen-Hua Ling, Hong-Hui Guo
    Medicine.2015; 94(20): e758.     CrossRef
  • Relationship between glycemic control and histochemical myeloperoxidase activity in neutrophils in patients with type 2 diabetes
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    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal